Endocrine Abstracts

Activation of the G-protein coupled receptor GPR54 (AXOR12, OT7T175) by peptide ligands (kisspeptins) encoded by the Kiss-1gene is central to acquisition of reproductive competency in mammals. Administration of exogenous kisspeptins stimulates GnRH release from hypothalamic neurons in several species including humans. To confirm that kisspeptins are the natural agonist of GPR54 in vivo and to determine if these ligands have additional physiological functions, we ...